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KMID : 0374919930140020289
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Inje Medical Journal
1993 Volume.14 No. 2 p.289 ~ p.292
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A Case of Status Epilepticus Controlled by Allopurinol Administration
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김용복
김용균/권성운/오세익/김철수/김예희
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Abstract
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Status epilepticus is a medical emergency needing immediate treatment to prevent organic brain damage. We experienced a refractory case of status epilepticus to conventional phenytoin administration which mandated barbiturate general anesthesia
and
carbamazepine trial. On recovery from the anesthesia, repeated seizures reappeared with the elevation of liver enzymes probably caused by phenytoin. Switching of phenytoin to phenobarbital up to a therapeutic level also failed to control the
seizure.
Allopurinol was added as an adjunctive agent to pheobarbital and the seizure subsided. Thought the exact pharmacologic mechanism of allopurinol has been unknown, the agent deserves a trial in the refractory case of status epilepticus to
conventional
treatment.
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KEYWORD
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